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September 1979

Pigmentation of Osteoma Cutis Caused by Tetracycline

Author Affiliations

From the Division of Dermatology, University of California, School of Medicine, San Diego.

Arch Dermatol. 1979;115(9):1087-1088. doi:10.1001/archderm.1979.04010090037020

Blue nodules developed in the skin of a patient with acne concomitant with the start of tetracycline therapy. When removed, these nodules were brown and histologic examination revealed a lamellate structure compatible with bone. Under ultraviolet light, these osteomas fluoresced yellow, indicating the presence of tetracycline. This suggests that tetracycline, combined with new bone formation, causes pigmentation of osteoma cutis.

(Arch Dermatol 115:1087-1088, 1979)