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October 1979

Transcutaneous Gamma Benzene Hexachloride Absorption and Toxicity in Infants and Children

Author Affiliations

From the Department of Pediatrics, Neonatal Biology Section (Dr Pramanik), and the Department of Internal Medicine, Dermatology Section (Dr Hansen), University of Arizona Health Sciences Center, Tucson.

Arch Dermatol. 1979;115(10):1224-1225. doi:10.1001/archderm.1979.04010100044018

A premature, malnourished infant had seizures and abnormal neurological function associated with topical gamma benzene hexachloride (lindane) therapy. The level of gamma benzene hexachloride in his blood was 17 times greater than expected after a single topical application of 1% gamma benzene hexachloride. Significant levels developed in another child's blood after repeated applications of small amounts to areas of dermatitis and excoriations on the skin. The use of topical gamma benzene hexachloride in pediatric patients is reviewed because of increased evidence of unpredictable absorption and toxicity.

(Arch Dermatol 115:1224-1225, 1979)

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