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December 1979

Dermatofibrosarcoma Protuberans Arising in a Site of Multiple Immunizations

Author Affiliations

From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia (Drs Morman, Lin, and Petrozzi), and the Dermatology Section of Philadelphia Veterans Administration Hospital (Dr Petrozzi). Dr Morman is presently with the Department of Dermatology, Cleveland Clinic Foundation.

Arch Dermatol. 1979;115(12):1453. doi:10.1001/archderm.1979.04010120049022

Benign dermatologic conditions, including sarcoidosis, erythema multiforme, urticaria, erythema nodosum, and others, have developed at the sites of vaccination.1 Scars from burns, x-rays, lupus vulgaris, lupus erythematosus, and chronic osteomyelitis are susceptible to cancerous change.2 The development of malignancy in vaccination scars is also a well-recognized event, with at least five different tumors having been described in vaccination sites: basal cell carcinoma, malignant melanoma, squamous cell carcinoma, fibrosarcoma, and dermatofibrosarcoma protuberans. We describe a patient in whom dermatofibrosarcoma protuberans developed at the site of multiple immunizations.

Report of a Case  A 33-year-old man had a rapidly growing mass in the deltoid region of his left arm. He had had multiple immunizations for plague, yellow fever, and tetanus at that site in 1965 at the time of his armed forces induction physical examination. His records were lost and he was subjected to the same injections into the same area