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February 1980

Cutaneous Reactions at Test Sites of Iodine-Containing Contrast Medium

Author Affiliations

Takamatsu, Japan

Arch Dermatol. 1980;116(2):157. doi:10.1001/archderm.1980.01640260033002

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To the Editor.—  Hysterosalpingography is useful in the study of sterility and myomatous uteri. Delayed cutaneous reactions developed in ten patients at the sites of intradermal injections of iodine-containing contrast medium (Iodized Oil) used for hysterosalpingography.

Report of Cases.—  Hysterosalpingography was used to study nine patients for sterility and one patient for myomatous uteri. An intradermal test with 0.1 mL of contrast medium (Iodized Oil) for hysterosalpingography was done on the forearm in each case to determine iodine sensitivity. Since these ten patients did not show immediate hypersensitivity after 15 minutes, hysterosalpingography was carried out in each. No patient experienced any systemic symptoms. After seven to 34 days, erythema, bullae, and swelling occurred at the injection sites in all ten patients (Fig 1). In one case, erythema extended to an area 135 × 80 mm around the reaction site. The eruption reached its maximum extent two to three days after

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