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February 1980

Kyrle's Disease and Type II Hyperlipoproteinemia

Author Affiliations

From the Dermatology Branch, National Cancer Institute (Dr Tomecki) and the Cardiology Division, National Heart and Lung Institute (Dr Battaglini), National Institutes of Health, Bethesda, Md; and the Department of Dermatology, State University of New York at Buffalo (Dr Maize). Dr Tomecki is now with the Division of Dermatology, University of Florida, Gainesville.

Arch Dermatol. 1980;116(2):227-228. doi:10.1001/archderm.1980.01640260103028

Kyrle's disease is an uncommon dermatosis of hyperkeratotic papules, with a distinctive histologic picture characterized by the penetration of a keratotic plug into the dermis. We report a case of Kyrle's disease in association with type II hyperlipoproteinemia.

Report of a Case  A 51-year-old man with a family history of diabetes mellitus had a personal history of proven nondietary type IIb hyperlipoproteinemia characterized by elevated plasma cholesterol and triglyceride levels; he also had known coronary artery disease and a three-year history of asymptomatic papules on both legs.Physical examination disclosed multiple well-demarcated, flesh-colored papules, with a central keratin plug, over the knees, as well as tibial tuberosities (Fig 1). The diagnosis at the time of examination was Kyrle's disease.A skin biopsy specimen of a keratotic papule showed marked invagination of the epidermis, filled with parakeratotic stratum corneum; absence of the granular layer beneath the parakeratotic horn, with marked thinning

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