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March 1980

Benign Leukokeratosis of the Areolae and Abdomen

Author Affiliations

From the Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minn. Dr Millns is currently with the Division of Dermatology, University of South Florida School of Medicine, Tampa.

Arch Dermatol. 1980;116(3):353-354. doi:10.1001/archderm.1980.01640270113028

Hyperkeratosis of the nipples and areolae is a rare disorder occurring predominantly in women and occasionally associated with additional hyperkeratotic conditions, that is, ichthyosis or epidermal nevi. Typically, the lesions have been characterized by diffuse thickening and brownish hyperpigmentation.

We report two cases of asymptomatic patches of irregular, white hyperkeratotic lesions occurring on the areolae. These cases were unusual because both patients had associated white lesions in the periumbilical area, were adult males, and responded to topical tretinoin therapy.

Report of Cases 

Case 1.—  The condition of a 47-year-old man was evaluated for an asymptomatic untreated eruption of one year's duration on the areolae and abdomen. No family history of similar lesions was noted.On examination, the patient had patches of irregular, white, adherent hyperkeratotic lesions of the areolae (Fig 1), as well as

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