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May 1980

Positive Cutaneous Immunofluorescence in Grover's Disease

Author Affiliations

Rochester, Minn

Arch Dermatol. 1980;116(5):515. doi:10.1001/archderm.1980.01640290025001

To the Editor.—  Transient acantholytic dermatosis (Grover's disease), first described in 1970,1 represents a unique condition of middle-aged and elderly persons; it is characterized by pruritic, discrete, erythematous, edematous papules and papulovesicles located predominantly on the trunk. The condition may last weeks to months and may be exacerbated by exposure to sunlight. During the past few years, several variations of this disorder have been reported. Waisman et al2 described three patients with a bullous variant of Grover's disease in which the histologic changes were identical to those of pemphigus foliaceus. Simon et al3 noted a patient with persistent acantholytic dermatosis who had a more prolonged course, and Heaphy et al4 coined the term "benign papular acantholytic dermatosis" for a similar group of seven patients.Scattered reports of direct immunofluorescence microscopy in Grover's disease have recorded negative results to date, with one exception.3 In that study,

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