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May 1980

Diminished Immune Response in Sun-Damaged Skin

Author Affiliations

From the Veterans Administration Hospital and Division of Dermatology, University of New Mexico School of Medicine, Albuquerque (Mr O'Dell and Drs Jessen, Becker, and Jackson) and the Department of Dermatology, University of Texas Medical Branch, Galveston (Dr Smith).

Arch Dermatol. 1980;116(5):559-561. doi:10.1001/archderm.1980.01640290069015

• In previously sensitized volunteers, higher concentrations of 2,4-dinitrochlorobenzene were necessary to elicit positive patch test reactions on the sundamaged skin of the neck than on the protected skin of the upper part of the back. This difference was not found in subjects without evidence of sun damage, and there was no difference between sundamaged and nondamaged skin in response to a primary irritant. Responses to intradermally injected common antigens were also less intense in sun-damaged skin than in nonexposed skin. These findings suggest the existence of a local defect in cell-mediated immunity in skin altered by long-term sun exposure.

(Arch Dermatol 116:559-561, 1980)

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