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May 1980

Cutaneous Macroglobulinosis

Author Affiliations

From the Departments of Dermatology (Drs Hanke, Steck, Bergfeld, and Gross), Immunopathology (Dr Valenzuela), Hematology-Oncology (Dr Weick), and Peripheral Vascular Disease (Dr Young), The Cleveland Clinic Foundation. Dr Hanke is now with Indiana University School of Medicine, Indianapolis.

Arch Dermatol. 1980;116(5):575-577. doi:10.1001/archderm.1980.01640290085021

• A patient with Waldenström's macroglobulinemia had firm, translucent papules and nodules on the extremities. Clinically, the skin lesions were suggestive of amyloidosis cutis. Histologically, a homogeneous eosinophilic material was observed in the upper dermis and encasing the hair follicles. Special histochemical stains, electron microscopy, and immunofluorescence microscopy identified the material as IgM.

(Arch Dermatol 116:575-577, 1980)

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