• There is an increased risk of malignancy (particularly skin carcinomas and malignant lymphomas) in patients who have genetically determined and acquired immunosuppression. Multiple cutaneous squamous and basal cell carcinomas of the face and scalp with adjacent lymphomatous infiltration of the skin developed in a patient with stage IVA diffuse poorly differentiated lymphocytic lymphoma. He had had one cycle of vincristine sulfate, prednisone, and cyclophosphamide therapy for his lymphoma more than one year before. He showed impaired delayed hypersensitivity responses on skin testing with common antigens and he had a low serum (IgG) level.
(Arch Dermatol 116:687-689, 1980)
Cohen C. Multiple Cutaneous Carcinomas and Lymphomas of the Skin. Arch Dermatol. 1980;116(6):687–689. doi:10.1001/archderm.1980.01640300075023
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: