• A 78-year-old man had an acute eruption of lesions that clinically resembled seborrheic keratoses. Microscopic examination of the lesions indicated acantholysis and dyskeratosis primarily in the granular layer. The patient's serum contained antibodies to intercellular substance. Direct immunofluorescence microscopy of a lesion demonstrated immunoglobulin deposition in the intercellular areas. Treatment with oral prednisone produced rapid resolution of the lesions. Patients in whom eruptive seborrheic keratoses (Leser-Trélat sign) develop should have histological examination of their lesions to rule out the diagnosis of pemphigus foliaceus.
(Arch Dermatol 116:815-816, 1980)
Bruckner N, Katz RA, Hood AF. Pemphigus Foliaceus Resembling Eruptive Seborrheic Keratoses. Arch Dermatol. 1980;116(7):815–816. doi:10.1001/archderm.1980.01640310085028
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.