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September 1980

Torre's Syndrome as Phenotypic Expression of Cancer Family Syndrome

Arch Dermatol. 1980;116(9):986-987. doi:10.1001/archderm.1980.01640330024003

To the Editor.—  Housholder and Zeligman1 recently described two patients with Torre's syndrome (TS) whose relatives also had visceral malignant neoplasms. Long survival was also noteworthy despite the occurrence of extensive visceral cancer. Their review of the literature disclosed several reports bearing on the occurrence of visceral malignant neoplasms in relatives of patients with TS.We have recently completed a study in which we clearly identify TS as the cutaneous phenotypic expression of the cancer family syndrome (CFS). The CFS is characterized by the following: (1) an early onset of colorectal cancer (preponderantly of the proximal colonic segment) in the absence of polyposis coli, (2) an association with other adenocarcinomas, particularly of the endometrium and ovary, (3) an excessive number of multiple primary cancers, (4) an occasional extraordinary tolerance of cancer,2 and (5) more recently, our observation of an association with sebaceous neoplasia in a fraction of relatives

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