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October 1980

Vasculitis in Cytomegalovirus Infection

Author Affiliations

From the Dermatology Service, Veterans Administration Medical Center (Drs Weigand and Burgdorf), and the Departments of Dermatology (Drs Weigand and Burgdorf) and Pediatrics (Dr Tarpay), University of Oklahoma Health Sciences Center, Oklahoma City.

Arch Dermatol. 1980;116(10):1174-1176. doi:10.1001/archderm.1980.01640340084023

• A 7-year-old girl had fever, arthralgia, and a mild cutaneous vasculitis with papules, nodules, and livedo. A biopsy specimen of a papule showed lymphocytic small-vessel vasculitis, with some atypical lymphocytic nuclei. Splenomegaly developed, and results of subsequent studies supported a diagnosis of cytomegalovirus (CMV) infection, with atypical peripheral blood lymphocytes and a characteristic pattern of complement-fixing antibodies to CMV antigen. The CMV mononucleosis syndrome is rarely reported in children, and the cutaneous manifestations are usually rubelliform. Distinctive cutaneous pathologic characteristics have been described previously only in neonates ("blueberry muffin" syndrome) and in immunosuppressed patients (viral inclusion bodies in endothelial cells).

(Arch Dermatol 116:1174-1176, 1980)