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November 1980

Inhibition of Rat Skin Ornithine Decarboxylase by Nitrofurazone

Author Affiliations

Durham, NC

Arch Dermatol. 1980;116(11):1225-1226. doi:10.1001/archderm.1980.01640350015001

To the Editor.—  Ornithine decarboxylase (ODC) is the first enzyme and a rate-limiting enzyme in the biosynthetic pathway for the polyamines (putrescine, spermidine, and spermine). Increases in skin ODC activity have been found to correlate with the administration of growth-promoting stimuli such as hair plucking,1 tumor promotion, and wounding.2 It has recently been reported that topical nitrofurazone (Furacin) treatment results in a substantial decrease in the rate of wound healing in pig skin.3 Inhibition of ornithine decarboxylase induction may form the biochemical basis of the clinically observed retardation of wound healing by nitrofurazone.

Technique.—  Samples of nitrofurazone soluble dressing and its polyethylene glycol vehicle were obtained. Hair was shaved from the dorsal skin of 8-week-old male