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December 1980

Elastosis Perforans Serpiginosa and Other Complications

Arch Dermatol. 1980;116(12):1348. doi:10.1001/archderm.1980.01640360022011

To the Editor.—  This is a follow-up and comment about a patient with elastosis perforans serpiginosa (EPS) who was previously described in the Archives.1 The patient is now 41 years old, has Down's syndrome, and has been confined to the Richmond State School, Tex. She was first seen in our clinic in 1946, when she was 8 years old. However, the EPS was first described in 1959.2 We have been seeing her regularly once or twice a year since that time. So far, all the treatments we have prescribed, including topical agents, ie, iodine, ethyl chloride, liquid nitrogen, tretinoin, many topical steroid preparations (with and without occlusion), tar, methotrexate, salicylic acid, and sulfur, have not helped. Agents given for systemic effect were used at different times, in different doses and combinations, ie, the administration of vitamins A and E, griseofulvin, zinc sulfate, and steroids, resulted in no changes