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December 1980

Poliomyelitis Vaccine in the Treatment of Behçet's Syndrome

Author Affiliations

Tel-Aviv, Israel

Arch Dermatol. 1980;116(12):1348. doi:10.1001/archderm.1980.01640360022012

To the Editor.—  The cause of Behçet's syndrome is unknown, and its therapy is unsatisfactory. One of the causative possibilities that has been entertained is a virus infection.1,2 Antipolio Sabin vaccine by oral administration has recently been reported by one of us (A.T.) to be of benefit in herpes simplex lesions of the skin3 and in a case of Behçet's syndrome.4 These observations prompted us to try the following therapy in a patient with active and severe Behçet's syndrome.

Report of a Case.—  A 22-year-old man was first seen in our clinic in 1976 because of arthritis in a knee, ankle, wrist, and elbow. He gave a five-year history of repeated oral mucosal ulcerations, pyoderma, scrotal ulcerations, recurrent thrombophlebitis, and bilateral uveitis. A saline skin test result was positive, and the diagnosis of Behçet's syndrome was made. Despite the administration of nonsteroidal and steroidal anti-inflammatory drugs, he