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March 1981

Aminonicotinamide in Pityriasis Rubra Pilaris

Author Affiliations

London, England

Oxford, England

Arch Dermatol. 1981;117(3):127. doi:10.1001/archderm.1981.01650030003002

To the Editor.—  Successful treatment of pityriasis rubra pilaris (PRP) using topical 1% aminonicotinamide in a hydrophilic ointment was reported in the article "Pityriasis Rubra Pilaris Responding to Aminonicotinamide" by Binnick in the September Archives (1978;114:1348-1349). All persons who have looked at the cell kinetics of this condition, using several different techniques, have found a hyperactive epithelium with increased DNA synthesis.1-7 Therefore, a successful treatment method might include a topical cytostatic agent.We wish to report our experience with this form of treatment in two other adult patients with an acute onset of PRP.

Report of Cases.—Case 1.—  On the skin of a 65-year-old woman, a red, scaly patch on the neck developed that had spread gradually, within eight weeks, to involve approximately 80% of her cutaneous surface. The palms and soles were thick and yellow, and perifollicular erythema was prominent in many other areas. Islands of unaffected skin

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