The speculations of Burch and Rowell concern- ing the mode of inheritance in psoriasis only emphasize the confusion and controversy surrounding this subject. While the bulk of current evidence, including our family with psoriasis that contained trizygotic triplets and dizygotic twins, lends support to an autosomal dominant mode of inheritance, the results of other studies are disparate enough to suggest, as Dobson has, that the genesis of psoriasis may be multifactorial, involving various heritable and nonheritable processes.It is difficult to see how one can maintain that inheritance of early-onset psoriasis is consistent with an X-linked dominant allele. In fact, Hoede1 proposed that psoriasis was inherited as an incompletely sex-limited irregular dominant, since more male than female subjects were affected in his survey of 1,437 patients with psoriasis and their families. Steinberg et al2 analyzed the families of 464 patients with psoriasis and concluded that there was no
Bernstein JE, Soltani K, Cutler LE. Mode of Inheritance in Psoriasis-Reply. Arch Dermatol. 1981;117(5):251–252. doi:10.1001/archderm.1981.01650050005006
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