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May 1981

Chromohyphomycosis: Treatment With Ketoconazole

Author Affiliations

From the Department of Dermatology (Dr South) and Division of Infectious Disease (Drs Brass and Stevens), Stanford (Calif) University Medical Center, and the Divisions of Dermatology (Dr South) and Infectious Disease (Dr Stevens), Santa Clara Valley Medical Center, San Jose, Calif.

Arch Dermatol. 1981;117(5):311-312. doi:10.1001/archderm.1981.01650050067028

Chromomycoses (CM) are a group of chronic, indolent ^ fungal infections of man and animals, in which the cutaneous and subcutaneous tissues are invaded by one of several species of dematiaceous (dark-brown or black) fungi.1 The term "chromohyphomycosis" (CHM) refers to a rare clinicopathologic subtype of CM manifested by a dermal nodule, in which discrete brown hyphae may be demonstrated.2 A patient with CHM was successfully treated with ketoconazole.

Report of a Case  A 56-year-old woman had a history of rapidly progressive renal failure and pulmonary hemorrhage developing in November 1978. An extensive workup failed to define the cause of either syndrome, but the patient was empirically treated with cyclophosphamide, 100 mg/day orally, and methylprednisolone sodium succinate, 50 mg/day intravenously (IV), between December 1978 and January 1979. A favorable response to this regimen was followed by maintenance therapy with prednisone alone, 20 mg/day orally, for the remainder of

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