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August 1981

Herpes Gestationis in Association With a Hydatidiform Mole: Immunopathologic Studies

Author Affiliations

From the Sections of Dermatology (Drs Tindall and Rea) and Clinical Immunology and Rheumatic Diseases (Dr Quismorio), and the Departments of Medicine and Pathology (Dr Shulman), University of Southern California School of Medicine, Los Angeles.

Arch Dermatol. 1981;117(8):510-512. doi:10.1001/archderm.1981.01650080064032

• A 28-year-old woman had an intensely pruritic eruption, consisting of plaques and vesicobullous lesions, three days after removal of a hydatidiform mole. Direct immunofluorescence (IF) microscopy of involved skin showed the linear deposition of C3 but no immunoglobulin along the basement membrane zone. Indirect IF microscopy disclosed a serum complement-fixing IgG antibody that reacted with the basement membrane of human adult and fetal skin. Thus, herpes gestationis can occur in association with a hydatidiform mole.

(Arch Dermatol 1981;117:510-512)

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