To the Editor.—
Giacosa et al1 described three patients with psoriasis who showed clinical improvement while being treated with 1 g/day of cimetidine.This observation prompted us to undertake a double-blind study to establish the effectiveness of cimetidine in the treatment of psoriasis. The study design randomized patients into one of two groups. The treatment group received 300 mg of oral cimetidine four times a day. The control group received placebo tablets four times a day. Patients were examined at weekly intervals during the four-week treatment period. To be eligible for the study, patients with a clinical diagnosis of psoriasis gave written informed consent and were able to discontinue all topical medications or medications given for systemic effect.The study was terminated (after nine patients had participated) because of the absence of noteworthy response in any patient and the difficulty in obtaining patients for the study.Results showed that
Long PR, Miller OF. Cimetidine and Psoriasis. Arch Dermatol. 1981;117(9):523. doi:10.1001/archderm.1981.01650090003002
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