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September 1981

Complement-Fixing Intercellular Antibodies

Arch Dermatol. 1981;117(9):528. doi:10.1001/archderm.1981.01650090008011

To the Editor.—  According to the recent report by Kumar et al in the July 1980 Archives (116:812-814), complementfixing (CF) intercellular (IC) antibodies in titers comparable to those seen by the ordinary indirect IgG test are a characteristic of pemphigus-like antibodies.Recently, 51 serum samples from untreated patients with pemphigus (clinically, histologically, and immunopathologically confirmed) were tested in our laboratory for the presence of CF IC antibodies. Six serum samples were found to have positive CF IC antibodies in titers greater than 1:20. In one case diagnosed as herpetiform pemphigus, the titer of CF IC antibodies (1:20) did not differ substantially from the titer of ordinary IgG antibodies (1:40). In addition, we could demonstrate IgG deposition in the IC spaces of organ-cultured human skin using pemphigus serum samples including CF IC antibodies; no C3 deposition was found. These bound IC antibodies were able to fix complement.We believe that the

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