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September 1981

Complement-Fixing Intercellular Antibodies-Reply

Arch Dermatol. 1981;117(9):528. doi:10.1001/archderm.1981.01650090008012

In Reply.—  Nishikawa and his associates point to their finding that six of 51 serum samples taken from patients with untreated pemphigus with IC antibodies had CF IC antibodies in titers of 1:20 or more and that one of these six serum samples (from a patient with herpetiform pemphigus) had a titer of CF antibodies comparable to that of the indirect immunofluorescence (IF) titer. In effect, 45 of 51 of their patients had either no detectable titers of CF antibodies or titers of less than 1:20. These findings are comparable to our own, with serum samples of patients with both pemphigus and pemphigoid. Specifically, the serum samples from four of ten patients with pemphigoidDifferences Between PAs and PLAs* Characteristics Observed PAs PLAs Coexistence of PAs and PLAs In vivo binding associated with acantholytic lesions Present in some, but not all, areas of normal skin and mucosa Not present if they exist

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