The Leser-Trélat sign is characterized by the sudden appearance and rapid increase in both the size and number of seborrheic keratoses. This paraneoplastic syndrome is most frequently associated with adenocarcinoma (67%), with the gastrointestinal (GI) tract being the most common primary tumor site (72%). However, in 22% of cases, the syndrome has been associated with lymphoproliferative malignant neoplasms. We describe herein a patient with the Leser-Trélat sign who had a lymphocytic lymphoma and later was found to have an adenocarcinoma of the large bowel.
Report of a Case
An obese, 59-year-old woman had a recent history of easy fatigability and malaise. Two months before, she had noticed the sudden appearance of many "warts" on her face and neck. On physical examination, multiple, 2- to 6-mm, seborrheic keratoses and numerous pigmented filariform papillomas were present on the neck and malar regions (Figure). Examination of the abdomen disclosed moderate hepatosplenomegaly. Findings from