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October 1981

Childhood Pemphigus Initially Seen as Eosinophilic Spongiosis

Author Affiliations

From the Department of Dermatology and the Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia.

Arch Dermatol. 1981;117(10):662-663. doi:10.1001/archderm.1981.01650100064032

• The condition of a 3-year-old boy with an intermittent, generalized, bullous eruption was initially diagnosed as (and treated as) bullous impetigo. After a relapse, two skin biopsies were performed. Each biopsy specimen showed the changes of eosinophilic spongiosis. A third biopsy specimen was also examined by direct immunofluorescence microscopy. The specimen showed deposition of IgG in the intercellular region of the epidermis. The patient's serum contained intercellular antibodies in a dilution of 1:160, confirming the diagnosis of pemphigus. A biopsy should be performed in the case of a child with a persistent or recurring bullous eruption; immunofluorescence microscopy of the biopsy is essential.

(Arch Dermatol 1981;117:662-663)

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