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October 1981

Granulomatous Perivasculitis in Crohn's Disease

Author Affiliations

From the Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City (Dr Burgdorf); and the Department of Dermatology, University of Minnesota Hospitals, Minneapolis (Dr Orkin).

Arch Dermatol. 1981;117(10):674-675. doi:10.1001/archderm.1981.01650100076036

Crohn's disease (CD) is a chronic inflammatory bowel disease characterized by noncaseating sterile granulomas. Similar histologic changes have been found in perianal skin, around stomal openings, in the oral cavity, and at distant cutaneous sites. In the latter situation, the term "metastatic Crohn's disease"1 has been employed.

Report of a Case  A 30-year-old woman with a 14-year history of CD of the small intestine and colon had had erythematous, red nodules involving all of her limbs for several months. About ten to 15 nodules had developed, some that were tender, and many that subsequently healed with hypopigmentation but without complicating ulceration, drainage, or scarring. Similar lesions had been present 12 years previously but had disappeared after the distal part of her involved ileum and proximal part of the colon had been resected. She was taking 500 mg/day of sulfasalazine and cyanocobalamin. She had been taking oral prednisone frequently during the

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