We agree that intercellular deposits of complement are found in the lesional areas of the skin of some patients with pemphigus. The serum samples of such patients with pemphigus have usually been shown not to fix complement. In contrast, intercellular antibodies in the serum samples of certain patients without pemphigus usually do fix complement, but the skin of these patients does not exhibit in vivo intercellular staining, thus differentiating pemphigus from pemphigus-like antibodies by these two criteria.Our studies have also indicated that complement C3 is found in the lesional skin of 31% of patients with pemphigus, which is in close approximation to the findings reported by Bystryn. In addition, we examined the presence of intercellular deposits in the normal skin of patients with pemphigus, and, as expected, in no patient (0/14) could we detect C3 staining, whereas IgG was present in 93% of such cases studied at
Kumar V, Beutner EH. Intercellular Deposits of Complement in Skin of Patients With Pemphigus-Reply. Arch Dermatol. 1981;117(11):682–683. doi:10.1001/archderm.1981.01650110004003
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