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December 1981

Treatment of Generalized Pustular Psoriasis With Methotrexate and Colchicine

Author Affiliations

Kyoto, Japan

Arch Dermatol. 1981;117(12):760. doi:10.1001/archderm.1981.01650120006008

To the Editor.—  It is widely accepted that colchicine exerts its anti-inflammatory effect by inhibiting chemotaxis of polymorphonuclear leukocytes. Diseases in which polymorphonuclear leukocytes play an important pathogenetic role have been treated successfully with this drug.1 We would like to report a case of generalized pustular psoriasis that showed notable improvement with methotrexate and colchicine therapy.

Report of a Case.—  A 32-year-old woman had had pustular psoriasis of the tongue and of the nailbeds of all digits for 17 years. In the 17th week of her second pregnancy, generalized pustular eruptions, fever, and malaise developed. There was no history of a similar eruption during her first pregnancy, which was terminated by abortion in the third month. An elevated ESR (100 mm/hr) and WBC count (20,500/cu mm, with 86% polymorphonuclear leukocytes) were noted. Serum examination results (including calcium level and urinalysis) were within normal limits. A biopsy specimen taken from

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