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February 1982

Pulse Therapy: Therapeutic Efficacy in the Treatment of Pyoderma Gangrenosum

Author Affiliations

From the Department of Medicine, Division of Dermatology, Duke University Medical Center, Durham, NC.

Arch Dermatol. 1982;118(2):76-84. doi:10.1001/archderm.1982.01650140008008

• Three patients with pyoderma gangrenosum were treated with suprapharmacologic doses of methylprednisolone sodium succinate using a five-day pulse therapy regimen. This therapy produced a dramatic remission with minimal side effects. The effects of pulse therapy are reviewed, and its role in severe steroid-responsive dermatoses is discussed.

(Arch Dermatol 1982;118:76-84)

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