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February 1982

Werner's Syndrome With Associated Malignant Neoplasms

Author Affiliations

From the Department of Dermatology, Roswell Park Memorial Institute, Buffalo (Drs Hrabko, Milgrom, and Schwartz); and the Department of Dermatology, University of California School of Medicine and Veterans Hospital, San Francisco (Dr Schwartz).

Arch Dermatol. 1982;118(2):106-108. doi:10.1001/archderm.1982.01650140038016

• Werner's syndrome is an autosomal recessive disease characterized by juvenile cataracts, scleroderma-like skin changes, and a high incidence of neoplasms. A 57-year-old man had Werner's syndrome associated with a fibrosarcoma of the mediastinum and multiple basal cell epitheliomas. In two of these basal cell epitheliomas, since the sclerotic skin made it difficult to assess the extent of the tumor, microscopically controlled excision (Mohs' chemosurgery technique) was employed.

(Arch Dermatol 1982;118:106-108)

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