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February 1982

Sarcoidosis: Proceedings of the International Symposium on Sarcoidosis

Author Affiliations

San Francisco

Arch Dermatol. 1982;118(2):140. doi:10.1001/archderm.1982.01650140072030

This well-edited and neatly published book on "firm," soft paper is the result of an international symposium on sarcoidosis that was held in Tokyo. It is publication 13, sponsored by the Japan Medical Research Foundation, and it culminates 18 years of activity of the Japan Sarcoidosis Committee. The book is appropriately divided into five, roughly equal sections. The first, on immunology, focuses on function rather than simple structure or enumeration of immunocytes. Still, no conclusive answer emerges to explain the immunologic anergy that characterizes sarcoidosis. The next section, on pathology, deals with a variety of subjects, such as immune complex vasculitis, allergic alveolitis, and an unsuccessful search for the pathogenetic chemical in Kveim "substances." Here one also finds yet another description of the granulomagenic effect of synthetic muramyl dipeptide, the minimal structure responsible for the adjuvant activity of bacterial cell walls. The authors make a fine point, namely, that lymphocyte

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