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March 1982

BCG Vaccine-Induced Lupus Vulgaris

Author Affiliations

From the Division of Dermatology, Department of Medicine, University of Hawaii John A. Burns School of Medicine (Dr Izumi) and the University of Hawaii Integrated Flexible Program (Dr Matsunaga), Honolulu.

Arch Dermatol. 1982;118(3):171-172. doi:10.1001/archderm.1982.01650150033017

• A case of intradermal BCG vaccination was complicated by a lupus-like tuberculosis cutis progressive for over 30 years. The patient had been vaccinated twice with BCG in the affected site. A review of other BCG vaccine-induced cases of lupus vulgaris indicates that the incidence of this complication is markedly increased following multiple BCG vaccinations, but is rare following a single BCG vaccination. In our patient a skin biopsy specimen was characteristic for lupus vulgaris. Acid-fast stains from the tissue and cultures from the affected site were negative. The patient was successfully treated with rifampin.

(Arch Dermatol 1982;118:171-172)

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