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May 1982

Plasmapheresis for Psoriasis

Author Affiliations

Petah Tiqva, Israel

Arch Dermatol. 1982;118(5):292. doi:10.1001/archderm.1982.01650170006008

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To the Editor.—  Some authors link psoriasis with the presence of autoantibodies and the absence of T suppressor cells.1 Plasmapheresis by way of elution of such autoantibodies may serve as a possible mode of therapy in psoriasis. Subsequent to the observation of Dau2 of the clearing of psoriasis after plasmapheresis, as well as our own observations of the clinical and immunologic effects of peritoneal dialysis on psoriasis,3,4 we decided to perform plasmapheresis and to evaluate its effect on the immunologic system in a patient with psoriasis. The result of this treatment was a complete lack of response of the psoriatic lesions, with no notable influence on the immunologic system.

Report of a Case.—  An 18-year-old man had been suffering from generalized, plaque-type psoriasis since the age of 17 years and had been treated only with fluoridated corticosteroid ointments (0.025% fluocinolone acetonide) under occlusive dressings. This mode of

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