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July 1982

Treatment of Pustulosis Palmaris et Plantaris With Oral Doses of Colchicine

Author Affiliations

From the Departments of Dermatology, Faculty of Medicine, Kyoto (Japan) University (Drs Takigawa and Miyachi); Shiga Medical School, Otsu, Japan (Dr Uehara); and Hamamatsu (Japan) Medical School (Dr Tagami).

Arch Dermatol. 1982;118(7):458-460. doi:10.1001/archderm.1982.01650190012009

• The effect of oral doses of colchicine on pustule formation was studied in 32 patients with pustulosis palmaris et plantaris without associated psoriasis. Oral administration of colchicine, 1 to 2 mg daily, was started during periods of disease exacerbation, and the dosage was gradually decreased to 0.5 to 1 mg daily in responsive patients. Thirteen patients showed complete clearing of pustulation, and 14 patients showed a remarkable reduction in pustule formation after two to eight weeks of treatment. One patient did not respond and four discontinued treatment because of nausea or diarrhea. During a three-month follow-up evaluation after treatment was stopped, relapse occurred in eight cases. Colchicine appears to be effective in the suppression of acute exacerbations of pustulosis palmaris et plantaris.

(Arch Dermatol 1982;118:458-460)

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