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July 1982

Enhanced Percutaneous Penetration With 1-Dodecylazacycloheptan-2-one

Author Affiliations

From the Division of Dermatology, School of Medicine, the University of California, San Diego.

Arch Dermatol. 1982;118(7):474-477. doi:10.1001/archderm.1982.01650190028013

• 1-Dodecylazacycloheptan-2-one (Azone) is a new agent that enhances the percutaneous absorption of a number of different chemicals. This report delineates the enhancement of penetration of clindamycin phosphate, erythromycin base, fusidate sodium, fluorouracil, desonide, amcinonide, and triamcinolone acetonide. For this purpose 1-dodecylazacycloheptan-2-one can be used in concentrations as low as 1%. It is colorless, relatively odorless, nontoxic, and can be applied neat to human skin without any irritation.

(Arch Dermatol 1982;118:474-477)

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