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July 1982

Reticulate Pigmented Anomaly of the Flexures: Case Reports and Genetic Investigation

Author Affiliations

From the Division of Dermatology, University of Maryland School of Medicine and Loch Raven Veterans Medical Center, Baltimore.

Arch Dermatol. 1982;118(7):490-493. doi:10.1001/archderm.1982.01650190044017

• Reticulate pigmented anomaly of the flexures is a pigmented macular disease characterized by punctate, hyperpigmented macules on the flexural areas. Histopathologic findings include acanthosis, keratinization of the follicular infundibulum, and filiform downgrowths of epidermal cells. Examination of a family has revealed the presence of the disease in six members. Analysis of these data suggests that reticulate pigmented anomaly of the flexures is an autosomal dominant genodermatosis with possibly variable penetrance, variable expressivity, and delayed onset.

(Arch Dermatol 1982;118:490-493)

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