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November 1982

Leprosy Downgrading Reaction Associated With Griseofulvin

Author Affiliations

From the Division of Dermatology, Department of Medicine, McGill University, Royal Victoria Hospital, Montreal.

Arch Dermatol. 1982;118(11):909-912. doi:10.1001/archderm.1982.01650230037024

† A dramatic alteration from clinically subpolar tuberculoid leprosy toward subpolar lepromatous leprosy was observed during griseofulvin therapy in a 29-year-old man, despite apparently normal cell-mediated immunity. To our knowledge, this is the first reported case of a downgrading reaction associated with griseofulvin. It is possible that this reaction was due to inhibition of polymorphonuclear leukocyte chemotaxis by griseofulvin.

(Arch Dermatol 1982;118:909-912)

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