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November 1982

Generalized Malignant Acanthosis Nigricans and Primary Fibrinolysis: Occurrence With Squamous Cell Carcinoma of the Uterine Cervix

Author Affiliations

From the Departments of Dermatology (Drs Azizi, Schewach-Millet, and Trau), Surgery (Drs Schneebaum, Rosenberg, and Ben-Ari), and Hematology (Dr Michelevicz), The Chaim Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel.

Arch Dermatol. 1982;118(11):955-956. doi:10.1001/archderm.1982.01650230083039

Generalized acanthosis nigricans is frequently regarded as a cutaneous marker of malignant disease, most often adenocarcinoma.1 Herein, an unusual case of generalized malignant acanthosis nigricans (GMAN) that accompanied squamous cell carcinoma of the uterine cervix is reported. The occurrene of primary fibrinolysis, a rare disorder sometimes associated with hematologic malignant neoplasms, prostate carcinoma, or pancreatic carcinoma,2 has not, to our knowledge, been reported previously in these circumstances.

Report of a Case  A 58-year-old woman with a three-year history of stage Ib squamous cell carcinoma of the uterine cervix was initially seen with erythroderma of several months' duration. During a threemonth period, we noticed a gradual onset of skin thickening and hyperpigmentation on the whole body (Fig 1), which was particularly severe in the flexural areas. There was progressive hair loss (Fig 2) and thickening, with white discoloration of the nails. Physical examination disclosed no other pathologic findings.A

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