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December 1982

Increased Helper-Suppressor T-cell Ratio in Psoriasis

Author Affiliations

From the Departments of Dermatology (Drs Ligresti and Lowney) and Pathology (Dr Neff), Ohio State University Hospitals, Columbus.

Arch Dermatol. 1982;118(12):966-970. doi:10.1001/archderm.1982.01650240010011

• Numerous investigations have suggested an immunologic pathogenesis of psoriasis and diminished suppressor T-cell activity of psoriatic blood. Consequently, a study was undertaken to explain whether diminished suppressor cell activity was a result of quantitative alterations of the T-lymphocyte subpopulation. Twenty patients with psoriasis and 20 normal control subjects were randomly selected. Our findings demonstrated a significant decrease in the percentage of suppressor cells (Tγ), a significant elevation of helper cells (Tμ), and a highly significant increase in the helper-suppressor T-cell ratio (Tμ/Tγ) of psoriatic blood compared with that of normal control subjects. Our study gives further support to the possible role of immunologic factors in the pathogenesis of psoriasis.

(Arch Dermatol 1982;118:966-970)

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