[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
January 1983

Systemic Pigmentation From Tetracycline and Minocycline Therapy

Author Affiliations

Bethesda, Md

Augusta, Ga

Arch Dermatol. 1983;119(1):1-2. doi:10.1001/archderm.1983.01650250005001

To the Editor.—  Minocycline hydrochloride is reported to be a safe and effective agent in the treatment of tetracycline-sensitive and tetracycline-resistant acne vulgaris.1 Long-term and high-dose administration of minocycline is known to cause blue or blue-black hyperpigmentation of the skin on the lower extremities, and atrophic scars.2 When tetracyclines are given over prolonged periods, brown-black microscopic discoloration of the thyroid gland is seen.3 Yellow bones have been noted following tetracycline therapy.4 This report describes clinical and postmortem findings of a patient treated with high-dose, long-term tetracycline hydrochloride and minocycline.

Report of a Case.—  In January 1978 a 19-year-old man was first seen in the dermatology clinic of Keller Army Hospital, West Point, NY, with grade II-III acne (Pillsbury classification). He had not received prior therapy for acne. He was given 250 mg of tetracycline hydrochloride four times daily and a topical erythromycin base lotion. Six weeks