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February 1983

Identification of T-cell Subpopulations in Granuloma Annulare

Author Affiliations

From the Departments of Dermatology (Drs Buechner and Winkelmann) and Surgical Pathology (Dr Banks), Mayo Clinic and Mayo Foundation, Rochester, Minn. Dr Buechner is a visiting clinician from the Department of Dermatology, University of Basel (Switzerland).

Arch Dermatol. 1983;119(2):125-128. doi:10.1001/archderm.1983.01650260033012

• Granuloma annulare is a lymphohistiocytic process of unknown cause characterized by necrobiotic dermal papules. Acetone-fixed frozen sections of eight granuloma annulare lesions were studied for the presence of T-cell subsets, using monoclonal antibodies to T-cell surface antigens. The palisading and perivascular lymphocytic infiltrate shows that most of the mononuclear cells are reactive with LEU-1 antibody, which characterizes peripheral T cells and activated T cells. Numerous cells were reactive with LEU-3a antibody, which identifies the helper-inducer T-cell subset. Some cells were positive with LEU-2a antibody, which detects suppressor-cytotoxic cell populations. Masses of histiocytes were identified infiltrating between the collagen fibers and surrounding the central necrobiosis area; the histiocytes showed a very strong diffuse acid phosphatase and nonspecific esterase activity. These findings suggest that a cell-mediated immune response may be the dominant pathogenic event in granuloma annulare.

(Arch Dermatol 1983;119:125-128)