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April 1983

Sensitivity to the Weed Killer DNA-nitralin and Cross-sensitivity to Dinitrochlorobenzene

Author Affiliations

From the Department of Dermatology, Yamaguchi (Japan) University School of Medicine.

Arch Dermatol. 1983;119(4):304-306. doi:10.1001/archderm.1983.01650280032011

• A man, with a dermatitis acquired while working in a factory producing a weed killer, showed sensitivity to 4-methylsulfonyl 2,6-dinitro-N,N-dipropylaniline (DNA-nitralin) and its precursor, 4-chloro 3,-5-dinitrophenylmethyl sulfone (DNC), and cross-sensitivity to dinitrochlorobenzene (DNCB). Sensitization capacities of DNA-nitralin and DNC compared with DNCB, and cross-sensitizations among 11 dinitrobenzene derivatives, including DNA-nitralin, DNC, and DNCB, were studied in guinea pigs. We found that the order of potency was DNCB, DNC, and DNA-nitralin for the sensitization capacity, and that cross-sensitizations may occur among DNCB, DNC, DNA-nitralin, and dinitrofluorobenzene, in comparatively high incidence.

(Arch Dermatol 1983;119:304-306)

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