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May 1983

Progressive Vaccinia Associated With Combined Variable Immunodeficiency

Author Affiliations

From the Departments of Dermatology (Drs Keane, Blankenship, and Pearson) and Immunology (Dr James), Rush-Presbyterian-St Luke's Medical Center, Chicago.

Arch Dermatol. 1983;119(5):404-408. doi:10.1001/archderm.1983.01650290044015

• Progressive vaccinia developed in a previously healthy woman following smallpox vaccination and was successfully treated with vaccinia immune human globulin and methisazone. Immunologic evaluation over the next 4½ years revealed evidence for combined variable immunodeficiency with increased numbers of circulating OKT 8 positive (suppressor-cytotoxic T) cells and the virtual absence of OKT 4 positive (helper-inducer T) cells.

(Arch Dermatol 1983;119:404-408)

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