[Skip to Navigation]
June 1983

Hailey-Hailey Disease: Response to Vitamin E Therapy

Author Affiliations

1245 Wilshire Blvd Los Angeles, CA 90017

Arch Dermatol. 1983;119(6):450. doi:10.1001/archderm.1983.01650300004002

To the Editor.—  In the October 1982 Archives (118:781-783) Michael presented a comprehensive commentary on the clinical, pathologic, etiologic, and therapeutic aspects of Hailey-Hailey disease, which is apparently associated with a genetic defect that was first reported by Hailey and Hailey in the April 1939 Archives under the name "familial benign chronic pemphigus."1 By a strange coincidence, the same condition was reported a few months later by Ayres and Anderson2 in the September 1932 Archives under the name "recurrent herpetiform dermatitis repens," five cases of which had been observed for more than 17 years.In 1975, Ayres and Mihan3 reported the successful control of the conditions of three patients with Hailey-Hailey disease by the oral administration of vitamin E in the form of d-α-tocopheryl acetate in doses of 800 to 1,200 IU/day. Exacerbation occurred on several occasions when the dose was notably reduced or the treatment stopped,