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July 1983

Anticentromere and Anticentriole Antibodies in the Scleroderma Spectrum

Author Affiliations

From the Departments of Dermatology (Dr Tuffanelli) and Biochemistry (Mr McKeon and Dr Kirschner), University of California, San Francisco; and the Department of Dermatology (Drs Kleinsmith and Burnham), Henry Ford Hospital, Detroit.

Arch Dermatol. 1983;119(7):560-566. doi:10.1001/archderm.1983.01650310022004

• We studied serum samples from 106 patients, including 80 in the scleroderma spectrum, by indirect immunofluorescent microscopy, using PtK, rat kangaroo tissue culture cells as substrate. Anticentromere (Kinetochore) antibodies were present in 28 patients, and anticentriole antibodies were present in four patients. Anticentromere antibodies were usually present in patients with a benign, chronic form of systemic scleroderma, which has been termed the CREST (Calcinosis, Raynaud's phenomenon, esophageal involvement, sclerodactyly, and telangiectasia) syndrome. The four patients with a previously undescribed anticentriole antibody were all in the scleroderma spectrum. Possibly, these antibodies may have diagnostic and prognostic importance. Further, they will be useful in studying the structure and function of these cellular organelles.

(Arch Dermatol 1983;119:560-566)