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August 1983

Carcinogenic Effect of Sequential Artificial Sunlight and UV-A Irradiation in Hairless Mice: Consequences for Solarium `Therapy'

Author Affiliations

From the Departments of Clinical Physiology (Dr Staberg), Dermatology (Drs Wulf, Klemp, and Brodthagen), and Pathology (Dr Poulsen), the Finsen Institute, Copenhagen.

Arch Dermatol. 1983;119(8):641-643. doi:10.1001/archderm.1983.01650320015008

• The carcinogenic effect of artificial UV sunlight followed by UV-A irradiation in human solaria doses has been studied with the use of the hairless mouse as an animal model. Artificial sunlight exposure alone induced only a moderate skin tumor incidence (animals with at least one tumor) of 0.15 after one year, and UV-A irradiation alone induced no tumor formation. However, the combination of artificial sunlight exposure and subsequent UV-A irradiation significantly increased the tumor incidence to 0.72. We conclude that, in humans, tanning with UV-A for cosmetic purposes may not be an innocuous procedure.

(Arch Dermatol 1983;119:641-643)

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