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August 1983

Demonstration of Treponema pallidum in a Cutaneous Gumma by Indirect Immunofluorescence

Author Affiliations

From the Seattle-King County Department of Public Health (Dr Handsfield); the Departments of Medicine, Harborview Medical Center, Seattle (Dr Handsfield); the Seattle Public Health Hospital (Drs Lukehart and Holmes); the University of Washington School of Medicine (Drs Handsfield, Lukehart, and Holmes); and the Department of Pathology, University of California School of Medicine, San Diego (Drs Sell and Norris).

Arch Dermatol. 1983;119(8):677-680. doi:10.1001/archderm.1983.01650320051016

Treponema pallidum was demonstrated in a cutaneous, tertiary syphilitic lesion by indirect immunofluorescence microscopy, but not by darkfield microscopy illumination or silver stain. The numerous organisms observed by this method may help explain the histologically vigorous tissue reaction in tertiary syphilis, despite the scarcity of organisms demonstrable by other methods.

(Arch Dermatol 1983;119:677-680)

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