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September 1983

Intra-arterial Reserpine for Raynaud's SyndromeSystemic Reactions Without Therapeutic Benefit

Arch Dermatol. 1983;119(9):733-735. doi:10.1001/archderm.1983.01650330025008

• Twenty-four patients classified as having Raynaud's disease or Raynaud's phenomenon were given bilateral brachial artery injections of reserpine or saline in a double-blind fashion. In the six weeks following injection, there was no indication that reserpine produced clinical improvement or changed vasomotor reactivity in the treated patients. However, intra-arterial reserpine did produce systemic cardiovascular effects lasting up to six weeks. It is concluded that intra-arterial reserpine as used in this study is an ineffective treatment for Raynaud's disease or Raynaud's phenomenon and may have significant adverse effects.

(Arch Dermatol 1983;119:733-735)