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September 1983

Intra-arterial Reserpine for Raynaud's Syndrome: Systemic Reactions Without Therapeutic Benefit

Author Affiliations

From the Departments of Psychiatry (Drs Surwit and Neal and Mr Allen) and Medicine (Drs Surwit, Gilgor, and Duvic), Duke University Medical Center, Durham, NC.

Arch Dermatol. 1983;119(9):733-735. doi:10.1001/archderm.1983.01650330025008

• Twenty-four patients classified as having Raynaud's disease or Raynaud's phenomenon were given bilateral brachial artery injections of reserpine or saline in a double-blind fashion. In the six weeks following injection, there was no indication that reserpine produced clinical improvement or changed vasomotor reactivity in the treated patients. However, intra-arterial reserpine did produce systemic cardiovascular effects lasting up to six weeks. It is concluded that intra-arterial reserpine as used in this study is an ineffective treatment for Raynaud's disease or Raynaud's phenomenon and may have significant adverse effects.

(Arch Dermatol 1983;119:733-735)