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September 1983

Small Volume Plasmapheresis in the Management of Porphyria Cutanea Tarda

Author Affiliations

From the Department of Dermatology, University of Ehime (Japan) School of Medicine.

Arch Dermatol. 1983;119(9):752-755. doi:10.1001/archderm.1983.01650330044012

• A 49-year-old man with porphyria cutanea tarda was treated with repeated small volume plasmapheresis. After the circadian change of urinary porphyrins was found to be higher between midnight and noon, approximately 250 mL of plasma was removed at 8 AM and was replaced by physiological saline. Clinical disease manifestations and abnormal laboratory findings rapidly improved following a total of 20 plasmaphereses during a 24-week period. The blood hemoglobin and plasma total protein levels were unchanged.

(Arch Dermatol 1983;119:752-755)

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