To the Editor.—
A letter to the editor in the December 1978 issue of The Lancet initiated a discussion of the usefulness of cimetidine therapy in patients with psoriasis or psoriatic arthritis.1 Regarding the efficacy of this therapeutic approach, a number of rather contradictory results were published, describing both beneficial and neutral effects on skin and/or joint lesions.2-5 Our observation of a single patient with psoriatic arthritis in whom the eruptions disappeared while he was receiving cimetidine therapy prompted us to study ten additional patients with this disease.Short-term cimetidine therapy (14 to 28 days) was started at a dosage of 1 g/day, with a reduction to 600 mg/day after two weeks. Eight of the patients suffering from both psoriasis and psoriatic arthritis were at the same time being treated with nonsteroidal anti-inflammatory drugs. In two psoriasis patients without arthritis, all oral as well as topical treatment was
Manger BF, Stix R, Beck AL, Kalden JR. Cimetidine and Psoriatic Arthritis. Arch Dermatol. 1983;119(10):792. doi:10.1001/archderm.1983.01650340002004
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